Hepatocellular Carcinoma Medical Exam MCQ Questions With Answers
A 55-year-old man presents to his primary care physician with complaints of fatigue, abdominal pain, and unintentional weight loss. His medical history is significant for hepatitis C virus infection. Which of the following tests would be most appropriate for initial evaluation of hepatocellular carcinoma in this patient?
a. Abdominal ultrasound
b. Magnetic resonance imaging (MRI)
c. Computed tomography (CT) scan
d. Alpha-fetoprotein (AFP) blood test
Answer: d. Alpha-fetoprotein (AFP) blood test. AFP is a tumor marker for hepatocellular carcinoma and can be elevated in patients with this condition. A high level of AFP in a patient with risk factors for hepatocellular carcinoma, such as chronic hepatitis B or C infection, can suggest the presence of a tumor.
A 60-year-old woman is found to have a liver mass on abdominal imaging performed for unrelated reasons. She has no symptoms and no significant medical history. Which of the following imaging modalities is most sensitive and specific for diagnosing hepatocellular carcinoma?
a. Abdominal ultrasound
b. Magnetic resonance imaging (MRI)
c. Computed tomography (CT) scan
d. Positron emission tomography (PET) scan
Answer: b. Magnetic resonance imaging (MRI). MRI is the most sensitive and specific imaging modality for the diagnosis of hepatocellular carcinoma. It can detect small lesions and can distinguish between benign and malignant liver masses.
A 62-year-old man with a history of chronic hepatitis B presents to his primary care physician with complaints of abdominal pain, bloating, and weight loss. On physical examination, the physician palpates a large, firm liver. Laboratory studies show elevated liver enzymes and AFP. What is the most likely diagnosis?
A. Cirrhosis
B. Hepatocellular carcinoma
C. Hepatitis B
D. Hepatitis C
Answer: B. Hepatocellular carcinoma. The patient's history of chronic hepatitis B and physical examination findings of a large, firm liver, along with elevated liver enzymes and AFP, are consistent with the diagnosis of hepatocellular carcinoma.
A 45-year-old woman presents to the emergency department with acute onset of right upper quadrant abdominal pain and nausea. A CT scan shows a large mass in the liver with evidence of invasion into the adjacent hepatic vein. A biopsy confirms the diagnosis of hepatocellular carcinoma. What is the most appropriate next step in management?
A. Surgical resection
B. Liver transplant
C. Palliative care
D. Chemotherapy
Answer: B. Liver transplant. The patient's young age and the diagnosis of hepatocellular carcinoma with vascular invasion make her a candidate for liver transplant, which is the treatment of choice in this scenario.
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